introduction paragangliomas are mostly localized in the adrenal medulla and they are usually pheochromocytomas, derived from the neural crest, but otherwise mesenteric paragangliomas are extremely rare tumors. case presentation in this article we represent a 59-year-old female with an abdominal mass and pain due to mesenteric paraganglioma. conclusions paragangliomas can occur as mesenteric tum...

OBJECTIVE To describe the clinical findings in a patient who developed a neurofibroma, meningioma, and choroidal melanoma. METHODS Clinical and histopathological findings of the case are reviewed and presented. RESULTS The patient had a right superolateral periorbital neurofibroma, a right sphenoid wing meningioma, and a left choroidal juxtapapillary malignant melanoma. All 3 tumors are der...

paragangliomas are neoplasms of neural crest origin. in the head and neck, they uncommonly involve the larynx. the distinction between paragangliomas and other neuroendocrine tumors can be difficult. precise diagnosis is important in order to optimize patient treatment. diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. here we report a 77-year-old woman wi...

objective: the neural crest is a transient structure of early vertebrate embryos that generates neural crest cells (nccs). these cells can migrate throughout the body and produce a diverse array of mature tissue types. due to the ethical and technical problems surrounding the isolation of these early human embryo cells, researchers have focused on in vitro studies to produce nccs and increase t...

Paragangliomas are neoplasms of neural crest origin. In the head and neck, they uncommonly involve the larynx. The distinction between paragangliomas and other neuroendocrine tumors can be difficult. Precise diagnosis is important in order to optimize patient treatment. Diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. Here we report a 77-year-old woman wi...

Pediatric tumors arise upon oncogenic transformation of stem/progenitor cells during embryonic development. Given this scenario, the existence of non-tumorigenic stem cells included within the aberrant tumoral niche, with a potential role in tumor biology, is an intriguing and unstudied possibility. Here, we describe the presence and function of non-tumorigenic neural crest-derived progenitor c...

The receptor tyrosine kinase RET is expressed in cell lineages derived from the neural crest and has a key role in regulating cell proliferation, migration, differentiation and survival during embryogenesis. Germline and somatic mutations in RET that produce constitutively activated receptors cause the cancer syndrome multiple endocrine neoplasia type 2 and several endocrine and neural-crest-de...